Description
This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs).
CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases.
CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine).
It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I